Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice

• Main Authors: Georg D. Duerr (Author), Daniela Dewald (Author), Eva J. Schmitz (Author), Luise Verfuerth (Author), Katharina Keppel (Author), Christine Peigney (Author), Alexander Ghanem (Author), Armin Welz (Author), Oliver Dewald (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims. Repetitive brief ischemia and reperfusion (I/R) is associated with left ventricular dysfunction during development of ischemic cardiomyopathy. We investigated the role of zinc-donor proteins metallothionein MT1 and MT2 in a closed-chest murine model of I/R. Methods. Daily 15-minute LAD-occlusi...