Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

• Main Authors: Jue Wang (Author), Abigail McVicar (Author), Yilin Chen (Author), Hong-Wen Deng (Author), Zhihe Zhao (Author), Wei Chen (Author), Yi-Ping Li (Author)
• Format: Book
• Published: Nature Publishing Group, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient mice (Atp6i −/− ) arrested tooth root formation, indicated by truncated Hertwig's epithelial root sheath (HERS) progression. Furthermore...