The GluN2B-Selective Antagonist Ro 25-6981 Is Effective against PTZ-Induced Seizures and Safe for Further Development in Infantile Rats

• Main Authors: Pavel Mareš (Author), Lucie Kozlová (Author), Anna Mikulecká (Author), Hana Kubová (Author)
• 格式: 图书
• 出版: MDPI AG, 2021-09-01T00:00:00Z.
• 主题: article
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The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in various CNS pathologies, including epilepsy. Because of its predominant expression in the immature brain, selective GluN2B antagonists are expected to be more effective early in postnatal development. The aim of this...