Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes

• Autori principali: Shohreh Taziki (Autore), Mohammad Reza Sattari (Autore), Siavoush Dastamalchi (Autore), Mohammad Ali Eghbal (Autore)
• Natura: Libro
• Pubblicazione: Tabriz University of Medical Sciences, 2015-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are involved in hepatic injury. Melatonin is an a...