Development and optimization of curcumin analog nano-bilosomes using 21.31 full factorial design for anti-tumor profiles improvement in human hepatocellular carcinoma: in-vitro evaluation, in-vivo safety assay

• Главные авторы: Haidy Abbas (Автор), Yasmin A. El-Feky (Автор), Majid Mohammad Al-Sawahli (Автор), Nehal M. EL-Deeb (Автор), Hala Bakr El-Nassan (Автор), Mariam Zewail (Автор)
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• Опубликовано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предметы: article
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Curcumin (CU) is a natural polyphenolic phytoingredient. CU has anti-inflammatory, anti-oxidant, and anticancer activities. The poor solubility, bioavailability, and stability of CU diminish its clinical application. Hence, structural modification of CU is highly recommended. The CU analog; 3,5-bis(...