Pyruvate dehydrogenase kinase 4 promotes ubiquitin-proteasome system‐dependent muscle atrophy

• Main Authors: Ibotombi Singh Sinam (Author), Dipanjan Chanda (Author), Themis Thoudam (Author), Min‐Ji Kim (Author), Byung‐Gyu Kim (Author), Hyeon‐Ji Kang (Author), Jung Yi Lee (Author), Seung‐Hoon Baek (Author), Shin‐Yoon Kim (Author), Bum Jin Shim (Author), Dongryeol Ryu (Author), Jae‐Han Jeon (Author), In‐Kyu Lee (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Muscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear. Pyruvate dehydrogenase kinase 4 (PDK4), a central regulat...