A 2,3-diphenylpyrido[1,2-a] pyrimidin-4-one derivative inhibits specific angiogenic factors induced by TNF-α

• Главные авторы: Serena Del Turco (Автор), Luca Quattrini (Автор), Rocchina Colucci (Автор), Melania Gaggini (Автор), Concettina La Motta (Автор), Giuseppina Basta (Автор)
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• Опубликовано: Elsevier, 2019-12-01T00:00:00Z.
• Предметы: article
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Low-grade chronic inflammation is a key process of angiogenesis in tumour progression. We investigated whether a synthetic analogue of apigenin, the 2-(3,4-dimethoxyphenyl)-3-phenyl-4H-pyrido[1,2-a] pyrimidin-4-one (called DB103), interfered with the mechanisms involved in the angiogenic process ind...