Development of Oral Tablets of Nebivolol with Improved Dissolution Properties, Based on Its Combinations with Cyclodextrins

• Päätekijät: Francesca Maestrelli (Tekijä), Marzia Cirri (Tekijä), Natascia Mennini (Tekijä), Silvia Fiani (Tekijä), Beatrice Stoppacciaro (Tekijä), Paola Mura (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2024-05-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

New oral tablets of nebivolol have been developed aiming to improve, by cyclodextrin (CD) complexation, its low solubility/dissolution properties-the main reason behind its poor/variable oral bioavailability. Phase-solubility studies, performed using βCD and highly-soluble βCD-derivatives, indicated...