Assessing the Influence of Urine pH on the Efficacy of Ciprofloxacin and Fosfomycin in Immunocompetent and Immunocompromised Murine Models of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Infection in the Lower Urinary Tract

• Main Authors: Soraya Herrera-Espejo (Author), Marta Carretero-Ledesma (Author), Manuel Anselmo Bahamonde-García (Author), Elisa Cordero (Author), Jerónimo Pachón (Author), María Eugenia Pachón-Ibáñez (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In vitro studies have suggested that acidic pH may reduce and increase the efficacy of ciprofloxacin and fosfomycin, respectively, when used to treat <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> infections. We assessed the effects of acidic, neutral, and alkaline...