BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice

• Main Authors: Eliza Bollinger (Author), Matthew Peloquin (Author), Jenna Libera (Author), Bina Albuquerque (Author), Evanthia Pashos (Author), Arun Shipstone (Author), Angela Hadjipanayis (Author), Zhongyuan Sun (Author), Gang Xing (Author), Michelle Clasquin (Author), John C. Stansfield (Author), Brendan Tierney (Author), Steven Gernhardt (Author), C. Parker Siddall (Author), Timothy Greizer (Author), Frank J. Geoly (Author), Sarah R. Vargas (Author), Lily C. Gao (Author), George Williams (Author), Mackenzie Marshall (Author), Amy Rosado (Author), Claire Steppan (Author), Kevin J. Filipski (Author), Bei B. Zhang (Author), Russell A. Miller (Author), Rachel J. Roth Flach (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms underlying these improvements. Methods: The rate li...