mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin

• Main Authors: Magalie Haissaguerre (Author), Amandine Ferrière (Author), Vincent Simon (Author), Nicolas Saucisse (Author), Nathalie Dupuy (Author), Caroline André (Author), Samantha Clark (Author), Omar Guzman-Quevedo (Author), Antoine Tabarin (Author), Daniela Cota (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Nutrient availability modulates reactive oxygen species (ROS) production in the hypothalamus. In turn, ROS regulate hypothalamic neuronal activity and feeding behavior. The mechanistic target of rapamycin complex 1 (mTORC1) pathway is an important cellular integrator of the action of nutr...