Exploring Structure-Activity Relationships of Niclosamide-Based Colistin Potentiators in Colistin-Resistant Gram-Negative Bacteria

• 主要な著者: Liam Berry (著者), Quinn Neale (著者), Rajat Arora (著者), Danyel Ramirez (著者), Marc Brizuela (著者), Ronald Domalaon (著者), Gilbert Arthur (著者), Frank Schweizer (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2024-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Colistin is primarily used as a last resort antibiotic against highly resistant Gram-negative bacteria (GNB). Rising rates of colistin resistance, however, may limit future use of this agent. The anthelmintic drug niclosamide has been shown to enhance colistin activity in combination therapy, but a...