Mechanistic insights into the rational design of masked antibodies

• Main Authors: Carolina T. Orozco (Author), Manuela Bersellini (Author), Lorraine M. Irving (Author), Wesley W. Howard (Author), David Hargreaves (Author), Paul W. A. Devine (Author), Elise Siouve (Author), Gareth J. Browne (Author), Nicholas J. Bond (Author), Jonathan J. Phillips (Author), Peter Ravn (Author), Sophie E. Jackson (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although monoclonal antibodies have greatly improved cancer therapy, they can trigger side effects due to on-target, off-tumor toxicity. Over the past decade, strategies have emerged to successfully mask the antigen-binding site of antibodies, such that they are only activated at the relevant site,...