Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer

• Main Authors: Shuxi Qiao (Author), Brianna LaViolette (Author), Brianna LaCarubba Paulhus (Author), Xiangping Li (Author), John Litchfield (Author), Zhenhong Li (Author), John C. Stansfield (Author), Richard L. Gieseck III (Author), Bei B. Zhang (Author), Danna M. Breen (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Inflammation is a hallmark of cachexia; however, effective anti‐inflammatory treatments have not yet been identified. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a key signalling node linking interleukin‐1 receptor (IL‐1R) and toll‐like receptor (TLR) activation to the...