Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

• Main Authors: Sidharta PN (Author), Melchior M (Author), Kankam MK (Author), Dingemanse J (Author)
• 格式: 圖書
• 出版: Dove Medical Press, 2019-03-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Patricia N Sidharta,1 Meggane Melchior,1 Martin K Kankam,2 Jasper Dingemanse1 1Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil CH-4123, Switzerland; 2Vince and Associates Clinical Research, Overland Park, KS 66211, USA Background: Aprocitentan is an orally active, dual en...