Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life

• Main Authors: Wojciech Krzyzanski (Author), Bradley Stockard (Author), Andrea Gaedigk (Author), Allison Scott (Author), Whitney Nolte (Author), Kim Gibson (Author), J. Steven Leeder (Author), Tamorah Lewis (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Indomethacin is used commonly in preterm neonates for the prevention of intracranial hemorrhage and closure of an abnormally open cardiac vessel. Due to biomedical advances, the infants who receive this drug in the neonatal intensive care unit setting have become younger, smaller, and less...