Effect of oseltamivir phosphate versus placebo on platelet recovery and plasma leakage in adults with dengue and thrombocytopenia; a phase 2, multicenter, double-blind, randomized trial.

• Main Authors: Rahajeng N Tunjungputri (Author), Silvita Fitri Riswari (Author), Setyo G Pramudo (Author), Lydia Kuntjoro (Author), Bachti Alisjahbana (Author), Harry Galuh Nugraha (Author), Andre van der Ven (Author), Muhammad Hussein Gasem (Author), Quirijn de Mast (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Thrombocytopenia, bleeding and plasma leakage are major complications of dengue. Activation of endogenous sialidases with desialylation of platelets and endothelial cells may underlie these complications. We aimed to assess the effects of the neuraminidase inhibitor os...