Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity

• المؤلفون الرئيسيون: Amr Sonousi (مؤلف), Rasha A. Hassan (مؤلف), Eman O. Osman (مؤلف), Amr M. Abdou (مؤلف), Soha H. Emam (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Nineteen new quinazolin-4(3H)-one derivatives 3a-g and 6a-l were designed and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds was tested in vitro against 60 different human cell lines. The most potent compound 6d displayed superior sub-micromolar antiprolifer...