Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

• Main Authors: Urmas Roostalu (Author), Casper B. G. Salinas (Author), Ditte D. Thorbek (Author), Jacob L. Skytte (Author), Katrine Fabricius (Author), Pernille Barkholt (Author), Linu M. John (Author), Vanessa Isabell Jurtz (Author), Lotte Bjerre Knudsen (Author), Jacob Jelsing (Author), Niels Vrang (Author), Henrik H. Hansen (Author), Jacob Hecksher-Sørensen (Author)
• Format: Book
• Published: The Company of Biologists, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is a basal ganglia movement disorder characterized by progressive degeneration of the nigrostriatal dopaminergic system. Immunohistochemical methods have been widely used for characterization of dopaminergic neuronal injury in animal models of PD, including the MPTP (1-...