Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform

• Main Authors: Laura-Oana Albulescu (Author), Adam Westhorpe (Author), Rachel H. Clare (Author), Christopher M. Woodley (Author), Nivya James (Author), Jeroen Kool (Author), Neil G. Berry (Author), Paul M. O'Neill (Author), Nicholas R. Casewell (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors that can be administered as early interventions ha...