Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF

• Main Authors: O. G. Gribakina (Author), R. V. Shevchenko (Author), G. B. Kolyvanov (Author), A. A. Litvin (Author), P. O. Bochkov (Author), S. S. Boyko (Author), V. P. Zherdev (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

He technique of quantitative determination of a new compound GIZH-298 in the rat blood plasma was developed and validated. Analysis was performed by HPLC-UV. The method was linear in the range of 100-5000 ng/ml. Recovery of GIZH-298 was 86,88 %. Limit of detection was 100 ng/ml.