Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment‐mediated protein nanocages for enhancing cancer biotherapy

• Main Authors: Fabiao Hu (Author), Changping Deng (Author), Yiwen Zhou (Author), Yuping Liu (Author), Tong Zhang (Author), Peiwen Zhang (Author), Zhangting Zhao (Author), Hui Miao (Author), Wenyun Zheng (Author), Wenliang Zhang (Author), Meiyan Wang (Author), Xingyuan Ma (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Regulation of the apoptotic pathway plays a critical role in inducing tumor cell death and circumventing drug resistance. Survivin protein is the strongest inhibitor of apoptosis found so far. It is highly expressed in several cancers and is a promising target for cancer therapy. However, c...