Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies

• Main Authors: Catherine eEakin (Author), Amanda eMiller (Author), Jennifer eKerr (Author), James eKung (Author), Alison eWallace (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This nonenzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration and other dis...