Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies

• Egile Nagusiak: Catherine eEakin (Egilea), Amanda eMiller (Egilea), Jennifer eKerr (Egilea), James eKung (Egilea), Alison eWallace (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This nonenzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration and other dis...