Modulation of Human Dendritic Cell Functions by Phosphodiesterase-4 Inhibitors: Potential Relevance for the Treatment of Respiratory Diseases

• Main Authors: Hoang Oanh Nguyen (Author), Laura Tiberio (Author), Fabrizio Facchinetti (Author), Giulia Ripari (Author), Valentina Violi (Author), Gino Villetti (Author), Valentina Salvi (Author), Daniela Bosisio (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibitors of phosphodiesterase-4 (PDE4) are small-molecule drugs that, by increasing the intracellular levels of cAMP in immune cells, elicit a broad spectrum of anti-inflammatory effects. As such, PDE4 inhibitors are actively studied as therapeutic options in a variety of human diseases characteri...