TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS

• Main Authors: Michelle L. Thompson (Author), Pan Chen (Author), Xiaohui Yan (Author), Hanna Kim (Author), Akeem R. Borom (Author), Nathan B. Roberts (Author), Kim A. Caldwell (Author), Guy A. Caldwell (Author)
• Format: Book
• Published: The Company of Biologists, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Molecular mechanisms underlying neurodegenerative diseases converge at the interface of pathways impacting cellular stress, protein homeostasis and aging. Targeting the intrinsic capacities of neuroprotective proteins to restore neuronal function and/or attenuate degeneration represents a potential...