Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma

• Main Authors: Songlin Liu (Author), Dun Yuan (Author), Yifeng Li (Author), Qi Qi (Author), Bingzhong Guo (Author), Shun Yang (Author), Jilin Zhou (Author), Lu Xu (Author), Tiange Chen (Author), Chenxing Yang (Author), Junyu Liu (Author), Buyan Li (Author), Li Yao (Author), Weixi Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulation of retinoblastoma (Rb) signaling pathway have been established as a requirement for glioblastoma (GBM) initiation and progression, which suggests that blockade of CDK4/6-Rb signaling axis for GBM treatment. Palbociclib, a selective inhibitor of the cyclin-dependent kinases CDK4/6, has...