Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

• Ngā kaituhi matua: Travis T. Mallard (Author), Richard Karlsson Linnér (Author), Andrew D. Grotzinger (Author), Sandra Sanchez-Roige (Author), Jakob Seidlitz (Author), Aysu Okbay (Author), Ronald de Vlaming (Author), S. Fleur W. Meddens (Author), Abraham A. Palmer (Author), Lea K. Davis (Author), Elliot M. Tucker-Drob (Author), Kenneth S. Kendler (Author), Matthew C. Keller (Author), Philipp D. Koellinger (Author), K. Paige Harden (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2022-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Summary: Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensional approaches to genetic discovery for the first...