Improved translation of stability for conjugated antibodies using an in vitro whole blood assay

• Main Authors: Aimee Fourie-O'Donohue (Author), Phillip Y. Chu (Author), Josefa dela Cruz Chuh (Author), Robert Tchelepi (Author), Siao Ping Tsai (Author), John C. Tran (Author), William S. Sawyer (Author), Dian Su (Author), Carl Ng (Author), Keyang Xu (Author), Shang-Fan Yu (Author), Thomas H. Pillow (Author), Jack Sadowsky (Author), Peter S. Dragovich (Author), Yichin Liu (Author), Katherine R. Kozak (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several components of a drug-conjugated antibody are known to influence stability: 1) the site of drug attachment on the antibody, 2) the linker used to...