Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice

• Main Authors: Sing-Young Chen (Author), Martina Beretta (Author), Ellen M. Olzomer (Author), Divya P. Shah (Author), Derek Y.H. Wong (Author), Stephanie J. Alexopoulos (Author), Isabella Aleksovska (Author), Joseph M. Salamoun (Author), Christopher J. Garcia (Author), Blake J. Cochran (Author), Kerry-Anne Rye (Author), Greg C. Smith (Author), Frances L. Byrne (Author), Margaret J. Morris (Author), Webster L. Santos (Author), James Cantley (Author), Kyle L. Hoehn (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Calorie restriction is a first-line treatment for overweight individuals with metabolic impairments. However, few patients can adhere to long-term calorie restriction. An alternative approach to calorie restriction that also causes negative energy balance is mitochondrial uncoupling, whic...