BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy

• Main Authors: Salar Farokhi Boroujeni (Author), Galaxia Rodriguez (Author), Kristianne Galpin (Author), Edward Yakubovich (Author), Humaira Murshed (Author), Dalia Ibrahim (Author), Sara Asif (Author), Barbara C. Vanderhyden (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinical trials are currently exploring combinations of PARP inhibitors and immunotherapies for the treatment of ovarian cancer, but their effects on the ovarian tumour microenvironment (TME) remain unclear. Here, we investigate how olaparib, PD-L1 monoclonal antibodies, and their combinati...