Quercetin 3, 3', 4', 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase

• Main Authors: Abdul Burhan Khan (Author), Neha Gupta (Author), Qudsia Rashid (Author), Irshad Ahmad (Author), Shadabi Bano (Author), Urfi Siddiqui (Author), Mohammad Abid (Author), Mohamad Aman Jairajpuri (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Design and synthesis of a novel 3, 3', 4', 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol) unlike PDI inhibitor quercetin 3-rutinos...