Schistosoma japonicum soluble egg antigens attenuate invasion in a first trimester human placental trophoblast model.

• Main Authors: Emily A McDonald (Author), Jennifer F Friedman (Author), Surendra Sharma (Author), Luz Acosta (Author), Sunthorn Pond-Tor (Author), Ling Cheng (Author), Eric S White (Author), Jonathan D Kurtis (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis affects nearly 40 million women of reproductive age, and is known to elicit a pro-inflammatory signature in the placenta. We have previously shown that antigens from schistosome eggs can elicit pro-inflammatory cytokine production from trophoblast cells specifically; however, the inf...