Prevention of Autoimmune Diabetes in NOD Mice by Dimethyl Fumarate

• Main Authors: Shiri Li (Author), Nosratola D. Vaziri (Author), Lourdes Swentek (Author), Chie Takasu (Author), Kelly Vo (Author), Michael J. Stamos (Author), Camillo Ricordi (Author), Hirohito Ichii (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress plays critical roles in the pathogenesis of diabetes. This study tested the hypothesis that by protecting β-cells against oxidative stress and inflammation, an Nrf2 activator, dimethyl fumarate (DMF), may prevent or delay the onset of type 1 diabetes in non-obese diabetic (NOD) mice...