Prevention of Autoimmune Diabetes in NOD Mice by Dimethyl Fumarate

• Glavni autori: Shiri Li (Autor), Nosratola D. Vaziri (Autor), Lourdes Swentek (Autor), Chie Takasu (Autor), Kelly Vo (Autor), Michael J. Stamos (Autor), Camillo Ricordi (Autor), Hirohito Ichii (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Oxidative stress plays critical roles in the pathogenesis of diabetes. This study tested the hypothesis that by protecting β-cells against oxidative stress and inflammation, an Nrf2 activator, dimethyl fumarate (DMF), may prevent or delay the onset of type 1 diabetes in non-obese diabetic (NOD) mice...