Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress

• मुख्य लेखकों: Bingdong Sui (लेखक), Jin Liu (लेखक), Chenxi Zheng (लेखक), Lei Dang (लेखक), Ji Chen (लेखक), Yuan Cao (लेखक), Kaichao Zhang (लेखक), Lu Liu (लेखक), Minyan Dang (लेखक), Liqiang Zhang (लेखक), Nan Chen (लेखक), Tao He (लेखक), Kun Xuan (लेखक), Fang Jin (लेखक), Ge Zhang (लेखक), Yan Jin (लेखक), Chenghu Hu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Nature Publishing Group, 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss, but the mechanisms and therapeutics remain incompletely elucidated. Here, we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenes...