Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress

• Main Authors: Bingdong Sui (Author), Jin Liu (Author), Chenxi Zheng (Author), Lei Dang (Author), Ji Chen (Author), Yuan Cao (Author), Kaichao Zhang (Author), Lu Liu (Author), Minyan Dang (Author), Liqiang Zhang (Author), Nan Chen (Author), Tao He (Author), Kun Xuan (Author), Fang Jin (Author), Ge Zhang (Author), Yan Jin (Author), Chenghu Hu (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss, but the mechanisms and therapeutics remain incompletely elucidated. Here, we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenes...