Novel 2-mercapto imidazole and triazole derivatives as potent TGR5 receptor agonists

• Main Authors: Sameer Agarwal (Author), Santosh Sasane (Author), Jeevan Kumar (Author), Brijesh Darji (Author), Hitesh Bhayani (Author), Shubhangi Soman (Author), Neelima Kulkarni (Author), Mukul Jain (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TGR5 is a bile acid G protein-coupled receptor (GPCR), which is an attractive therapeutic target for the treatment of obesity, and its highly associated Type 2 diabetes. Activation of TGR5 promotes secretion of glucagon like peptide-1 (GLP-1) and activates insulin secretion. Series of novel 2-mercap...