Establishment and maintenance of the human naïve CD4+ T-cell compartment

• Main Authors: Susana L Silva (Author), Ana E Sousa (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The naïve CD4+ T-cell compartment is considered essential to guarantee immune competence throughout life. Its replenishment with naïve cells with broad diverse receptor repertoire, albeit with reduced self-reactivity, is ensured by the thymus. Nevertheless, cumulative data support a major requirem...