Comparison of PLA-Based Micelles and Microspheres as Carriers of Epothilone B and Rapamycin. The Effect of Delivery System and Polymer Composition on Drug Release and Cytotoxicity against MDA-MB-231 Breast Cancer Cells

• Main Authors: Katarzyna Jelonek (Author), Alicja Zajdel (Author), Adam Wilczok (Author), Bożena Kaczmarczyk (Author), Monika Musiał-Kulik (Author), Anna Hercog (Author), Aleksander Foryś (Author), Małgorzata Pastusiak (Author), Janusz Kasperczyk (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Co-delivery of epothilone B (EpoB) and rapamycin (Rap) increases cytotoxicity against various kinds of cancers. However, the current challenge is to develop a drug delivery system (DDS) for the simultaneous delivery and release of these two drugs. Additionally, it is important to understand the rele...