Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets

• Main Authors: John J. Shin (Author), Qurratulain Aftab (Author), Pamela Austin (Author), Jennifer A. McQueen (Author), Tak Poon (Author), Shu Chen Li (Author), Barry P. Young (Author), Calvin D. Roskelley (Author), Christopher J. R. Loewen (Author)
• Format: Book
• Published: The Company of Biologists, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stress. To compensate, tumour cells upregulate acid pu...