ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer

• Main Authors: Wenyu Wang (Author), Jihye Im (Author), Soochi Kim (Author), Suin Jang (Author), Youngjin Han (Author), Kyung-Min Yang (Author), Seong-Jin Kim (Author), Danny N. Dhanasekaran (Author), Yong Sang Song (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin resistance remains a significant obstacle for improving the clinical outcome of ovarian cancer patients. Recent studies have demonstrated that cisplatin is an important inducer of intracellullar reactive oxygen species (ROS), triggering cancer cell death. Sirtuin 2 (SIRT2), a member of cla...