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A Novel Foodstuff Mixture Improves the Gut-Liver Axis in MASLD Mice and the Gut Microbiota in Overweight/Obese Patients

Microbial community control is crucial for maintaining homeostasis of the gut-liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that supplementation with a mixture of Mexican foodstuffs (MexMix)-<i>Opuntia ficus indica</i> (nopal), <i>The...

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Main Authors: Rebeca Rosas-Campos (Author), Ana Soledad Sandoval-Rodríguez (Author), Jonathan Samael Rodríguez-Sanabria (Author), Ángel Omar Vazquéz-Esqueda (Author), Carlos Roberto Alfaro-Martinez (Author), Rebeca Escutia-Gutiérrez (Author), Natali Vega-Magaña (Author), Marcela Peña-Rodríguez (Author), José Sergio Zepeda-Nuño (Author), Mauricio Andrade-Marcial (Author), Yolanda Campos-Uscanga (Author), Luis Felipe Jave-Suárez (Author), Arturo Santos (Author), Eira Cerda-Reyes (Author), Mónica Almeida-López (Author), Erika Martínez-López (Author), Luis Alonso Herrera (Author), Juan Armendariz-Borunda (Author)
Format: Book
Published: MDPI AG, 2024-05-01T00:00:00Z.
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Summary:Microbial community control is crucial for maintaining homeostasis of the gut-liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that supplementation with a mixture of Mexican foodstuffs (MexMix)-<i>Opuntia ficus indica</i> (nopal), <i>Theobroma cacao</i> (cocoa) and <i>Acheta domesticus</i> (crickets)-enriches several beneficial taxa in MASLD mice and overweight/obese humans. Thus, MexMix induces an important prebiotic effect. In mice, a restoration of intestinal health was observed due to the increased short-chain fatty acids (SCFAs) and intestinal crypt depth, <i>Ocln</i> and <i>Cldn1</i> expression, and decreased <i>Il6</i> and <i>Tnfa</i> expression. MexMix significantly reduced steatosis in the mice's liver and modified the expression of 1668 genes. By PCR, we corroborated a <i>Tnfa</i> and <i>Pparg</i> decrease, and a <i>Cat</i> and <i>Sod</i> increase. In addition, MexMix increased the hepatic NRF2 nuclear translocation and miRNA-34a, miRNA-103, and miRNA-33 decline. In overweight/obese humans, MexMix improved the body image satisfaction and reduced the fat intake. These findings indicate that this new food formulation has potential as a therapeutic approach to treat conditions associated with excessive consumption of fats and sugars.
Item Description:10.3390/antiox13060664
2076-3921

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