A Novel Foodstuff Mixture Improves the Gut-Liver Axis in MASLD Mice and the Gut Microbiota in Overweight/Obese Patients
Microbial community control is crucial for maintaining homeostasis of the gut-liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that supplementation with a mixture of Mexican foodstuffs (MexMix)-<i>Opuntia ficus indica</i> (nopal), <i>The...
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MDPI AG,
2024-05-01T00:00:00Z.
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| 001 | doaj_e4b31ce2e0984e558e5408083094e0b5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rebeca Rosas-Campos |e author |
| 700 | 1 | 0 | |a Ana Soledad Sandoval-Rodríguez |e author |
| 700 | 1 | 0 | |a Jonathan Samael Rodríguez-Sanabria |e author |
| 700 | 1 | 0 | |a Ángel Omar Vazquéz-Esqueda |e author |
| 700 | 1 | 0 | |a Carlos Roberto Alfaro-Martinez |e author |
| 700 | 1 | 0 | |a Rebeca Escutia-Gutiérrez |e author |
| 700 | 1 | 0 | |a Natali Vega-Magaña |e author |
| 700 | 1 | 0 | |a Marcela Peña-Rodríguez |e author |
| 700 | 1 | 0 | |a José Sergio Zepeda-Nuño |e author |
| 700 | 1 | 0 | |a Mauricio Andrade-Marcial |e author |
| 700 | 1 | 0 | |a Yolanda Campos-Uscanga |e author |
| 700 | 1 | 0 | |a Luis Felipe Jave-Suárez |e author |
| 700 | 1 | 0 | |a Arturo Santos |e author |
| 700 | 1 | 0 | |a Eira Cerda-Reyes |e author |
| 700 | 1 | 0 | |a Mónica Almeida-López |e author |
| 700 | 1 | 0 | |a Erika Martínez-López |e author |
| 700 | 1 | 0 | |a Luis Alonso Herrera |e author |
| 700 | 1 | 0 | |a Juan Armendariz-Borunda |e author |
| 245 | 0 | 0 | |a A Novel Foodstuff Mixture Improves the Gut-Liver Axis in MASLD Mice and the Gut Microbiota in Overweight/Obese Patients |
| 260 | |b MDPI AG, |c 2024-05-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox13060664 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a Microbial community control is crucial for maintaining homeostasis of the gut-liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that supplementation with a mixture of Mexican foodstuffs (MexMix)-<i>Opuntia ficus indica</i> (nopal), <i>Theobroma cacao</i> (cocoa) and <i>Acheta domesticus</i> (crickets)-enriches several beneficial taxa in MASLD mice and overweight/obese humans. Thus, MexMix induces an important prebiotic effect. In mice, a restoration of intestinal health was observed due to the increased short-chain fatty acids (SCFAs) and intestinal crypt depth, <i>Ocln</i> and <i>Cldn1</i> expression, and decreased <i>Il6</i> and <i>Tnfa</i> expression. MexMix significantly reduced steatosis in the mice's liver and modified the expression of 1668 genes. By PCR, we corroborated a <i>Tnfa</i> and <i>Pparg</i> decrease, and a <i>Cat</i> and <i>Sod</i> increase. In addition, MexMix increased the hepatic NRF2 nuclear translocation and miRNA-34a, miRNA-103, and miRNA-33 decline. In overweight/obese humans, MexMix improved the body image satisfaction and reduced the fat intake. These findings indicate that this new food formulation has potential as a therapeutic approach to treat conditions associated with excessive consumption of fats and sugars. | ||
| 546 | |a EN | ||
| 690 | |a <i>Opuntia ficus indica</i> | ||
| 690 | |a <i>Theobroma cacao</i> | ||
| 690 | |a <i>Acheta domesticus</i> | ||
| 690 | |a MASLD | ||
| 690 | |a Mexican diet | ||
| 690 | |a obesity | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 13, Iss 6, p 664 (2024) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/13/6/664 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e4b31ce2e0984e558e5408083094e0b5 |z Connect to this object online. |