Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures

• Main Authors: Alaa S. Tulbah (Author), Mohammed H. Elkomy (Author), Randa Mohammed Zaki (Author), Hussein M. Eid (Author), Essam M. Eissa (Author), Adel A. Ali (Author), Heba A. Yassin (Author), Basmah Nasser Aldosari (Author), Ibrahim A. Naguib (Author), Amira H. Hassan (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan (LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect of three independent factors (Span 60 amount, chitosan concentration, and cholesterol amount) on vesicle size, entrapment eff...