Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis

• Main Authors: Jing Wen (Author), Yunhao Li (Author), Yanzhu Qin (Author), Lingli Yan (Author), Ke Zhang (Author), Ang Li (Author), Ziying Wang (Author), Feng Yu (Author), Jianheng Lai (Author), Wei Yang (Author), Yong U. Liu (Author), Dajiang Qin (Author), Huanxing Su (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aggregation of TAR-DNA binding protein-43 (TDP-43) is a pathological feature present in nearly 97 % cases of amyotrophic lateral sclerosis (ALS), making it an attractive target for pathogenic studies and drug screening. Here, we have performed a high-throughput screening of 1500 compounds from a nat...