Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies

• Main Authors: Fang Cheng (Author), Ruoqi Zhang (Author), Chen Sun (Author), Qian Ran (Author), Cuihan Zhang (Author), Changhong Shen (Author), Ziqing Yao (Author), Miao Wang (Author), Lin Song (Author), Cheng Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin-based chemotherapy is a standard treatment approach for colorectal cancer (CRC). However, oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe dose-limiting clinical problem that might lead to treatment interruption. This neuropathy may be reversible after treatment discontinu...