Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin

• Main Authors: Xiaoling Zhong (Author), Ashok Narasimhan (Author), Libbie M. Silverman (Author), Andrew R. Young (Author), Safi Shahda (Author), Sheng Liu (Author), Jun Wan (Author), Yunlong Liu (Author), Leonidas G. Koniaris (Author), Teresa A. Zimmers (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal adenocarcinoma (PDAC). The reproductive hormone and cytokine Activin is a mediator of PDAC cachexia, and Activin receptor targeting was clinically tested for cancer cachexia therapy. However, sex‐sp...