A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers

• Main Authors: Yuqing Meng (Author), Jiayun Chen (Author), Yanqing Liu (Author), Yongping Zhu (Author), Yin-Kwan Wong (Author), Haining Lyu (Author), Qiaoli Shi (Author), Fei Xia (Author), Liwei Gu (Author), Xinwei Zhang (Author), Peng Gao (Author), Huan Tang (Author), Qiuyan Guo (Author), Chong Qiu (Author), Chengchao Xu (Author), Xiao He (Author), Junzhe Zhang (Author), Jigang Wang (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The composition of serum is extremely complex, which complicates the discovery of new pharmacodynamic biomarkers via serum proteome for disease prediction and diagnosis. Recently, nanoparticles have been reported to efficiently reduce the proportion of high-abundance proteins and enrich low-abundanc...