Quercitrin neutralizes sPLA2IIa activity, reduces the inflammatory IL-6 level in PC3 cell lines, and exhibits anti-tumor activity in the EAC-bearing mice model

• Main Authors: P. Sophiya (Author), Deepadarshan Urs (Author), Jafar K. Lone (Author), A. S. Giresha (Author), H. Krishna Ram (Author), J. G. Manjunatha (Author), Hamed A. El-Serehy (Author), M. Narayanappa (Author), J. Shankar (Author), Ragini Bhardwaj (Author), Sameer Ahmad Guru (Author), K. K. Dharmappa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human phospholipase A2 group IIa (sPLA2IIa) is an inflammatory enzyme that plays a significant role in tumorigenesis. Inhibiting the sPLA2IIa enzyme with an effective molecule can reduce the inflammatory response and halt cancer progression. The present study evaluates quercitrin, a biflavonoid, for...