A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

• Main Authors: Julie K. Buick (Author), Andrew Williams (Author), Matthew J. Meier (Author), Carol D. Swartz (Author), Leslie Recio (Author), Rémi Gagné (Author), Stephen S. Ferguson (Author), Bevin P. Engelward (Author), Carole L. Yauk (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip® assay with the TGx-DDI transcriptomic biomarker (DDI = DNA damage-inducin...