GLT25D2 Is Critical for Inflammatory Immune Response to Promote Acetaminophen-Induced Hepatotoxicity by Autophagy Pathway

• Main Authors: Xiaohui Zhang (Author), Lele Guo (Author), Xiangying Zhang (Author), Ling Xu (Author), Yuan Tian (Author), Zihao Fan (Author), Hongshan Wei (Author), Jing Zhang (Author), Feng Ren (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) overdose induces hepatocyte necrosis and causes liver hepatotoxicity. Currently, the role of galactosyltransferase in APAP-induced liver injury is still unclear. This study assessed the contribution of the GLT25D2 gene, a kind of collagen galactosyltransferase, to the developmen...