miR-34a induces neutrophil apoptosis by regulating Cdc42-WASP-Arp2/3 pathway-mediated F-actin remodeling and ROS production

• Main Authors: Meiwan Cao (Author), Baoling Peng (Author), Huan Chen (Author), Min Yang (Author), Peiyu Chen (Author), Liping Ye (Author), Hongli Wang (Author), Lu Ren (Author), Jing Xie (Author), Jingnan Zhu (Author), Xiangye Xu (Author), Wanfu Xu (Author), Lanlan Geng (Author), Sitang Gong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background The number of neutrophils is significantly reduced in myelodysplastic syndrome (MDS), but the molecular basis remains unclear. We recently found that miR-34a was significantly increased in MDS neutrophils. Therefore, this study aims to clarify the effects of aberrant miR-34a expression on...